Colorectal Cancer Screening in Adults with Cystic Fibrosis at Increased Risk of CRC

With advances in treating Cystic Fibrosis (CF), CF patients are living into middle age. However, with this increased survivorship, the risk of colorectal cancer (CRC) has also increased compared to the general average-risk population. We partnered with the Cystic Fibrosis Foundation to assess the cost-effectiveness of screening in the CF population, and to develop screening recommendations from these results. The MISCAN-Colon model was adjusted to the increased risk of CRC in CF patients (with and without organ transplant). Colonoscopy every 5 years starting at age 40 was the optimal strategy for CF patient without an organ transplant, and colonoscopy starting at age 30‒35 was suggested for CF patients with an organ transplant. Methods and recommendations are described in more detail in this publication.