Bladder Cancer Modeling

The CISNET Bladder Working Group, funded as a CISNET Incubator Program cancer site, comprises two modeling groups and a coordinating center. The investigators are focused on completing the development, calibration and validation of two independent population models of bladder cancer and will address questions on its prevention, diagnosis, treatment, and surveillance by means of comparative mathematical modeling. The specific aims are:

  1. Develop, calibrate, and validate two independent population models of bladder cancer.
  2. Estimate the impact of carcinogens on past bladder cancer outcomes.
  3. Estimate the population impact of widespread implementation of carcinogen control policies on bladder cancer prevention.
  4. Determine the potential effectiveness of screening for bladder cancer among high-risk subgroups.
  5. Determine the effectiveness and cost-effectiveness of risk-based surveillance strategies for patients with non-muscle invasive bladder cancer.
  6. Determine the comparative effectiveness of treatments for organ-confined bladder cancer.