Uterine Cancer Modeling

The Uterine Cancer Working Group, funded as an Incubator Program cancer site, consists of three modeling groups and a coordinating center. The incidence and mortality of uterine cancer are rising dramatically in the U.S., especially among Black persons. The investigators are developing three natural history models of uterine to estimate the harms, benefits and cost-effectiveness of screening, prevention and treatment options for uterine cancer. They will likewise use these models to address areas of public health relevance including racial disparities, the growing obesity epidemic in the U.S., and changing rates of hysterectomy for benign gynecologic disease, all of which will have profound effects on the incidence and mortality of uterine cancer in the coming decades. The specific aims are:

  1. Estimate the contribution of changing epidemiologic and environmental factors in racial disparities in the
  2. Estimate the effectiveness and cost-effectiveness of prevention, screening, early detection, and surgical prophylaxis of uterine cancer in average risk women, high-risk women, and those with a genetic predisposition to uterine cancer (Lynch syndrome).
  3. Project the impact of obesity trends and evaluate the role of obesity prevention and control initiatives on uterine cancer incidence, mortality, and racial disparities.
  4. Explore the impact of benign uterine conditions and their management on disparities in uterine cancer incidence and mortality.
  5. Estimate the effectiveness and cost-effectiveness of novel therapeutic strategies for women with uterine cancer.