Comparison Grids and Model Profiles

Model Comparison Grids

The comparison grids were designed to highlight important characteristics about model design, assumptions, and inputs. They provide snapshots of key model differences and similarities within a cancer site.

• Bladder (PDF, 145 KB)
• Breast (PDF, 112 KB)
• Cervical (PDF, 115 KB)
• Colorectal (PDF, 398 KB)
• Gastric (PDF, 151 KB)
• Lung (PDF, 161 KB)
• Multiple Myeloma (PDF, 71 KB)
• Uterine (PDF, 115 KB)

Historical Versions

Bladder model profiles

The three bladder cancer modeling groups are using comparative modeling address major questions in the surveillance, treatment, prevention, and diagnosis of bladder cancer.

Model Comparison Grid (PDF, 145 KB)

Individual Models

• Kystis (Brown) In progress
• Cobras (Ottawa) In progress
• SCOUT (NYU) In progress

Historical Versions

Breast model profiles

Six breast cancer modeling groups use nationally-representative, up-to-date common data inputs to address policy-relevant questions related to risk-based breast cancer screening and targeted treatment.

Model Comparison Grid (PDF, 112 KB)
Joint Profiles - all profiles combined (PDF, 2.3 MB)

Individual Models

• UWBCS (Wisconsin) (PDF, 592 KB)
• BCOS (Stanford) (PDF, 510 KB)
• CISNET-DFCI (Dana-Farber) (PDF, 545 KB)
• MISCAN-Fadia (Erasmus) (PDF, 390 KB)
• Spectrum/G-E (Georgetown/Einstein) (PDF, 232 KB)
• Bayesian Simulation Model (MDACC) (PDF, 363 KB)

Historical Versions

Cervical model profiles

Five cervical cancer modeling groups use nationally-representative, up-to-date common data inputs to address policy-relevant questions related to risk-based cervical cancer screening and targeted treatment.

Model Comparison Grid (PDF, 115 KB)

Individual Models

• MGH-Cervical (MGH) (PDF, 600 KB)
• HSPH-Cervical (Harvard) (PDF, 298 KB)
• UMN-Cervical (Minnesota) (PDF, 379 KB)
• STDSIM-MISCAN-cervix (Erasmus) (PDF, 739 KB)
• Policy1-Cervix (UYSD) (PDF, 236 KB)

Historical Versions

Colorectal model profiles

Three colorectal cancer (CRC) modeling groups use nationally-representative, up-to-date common data inputs to address policy-relevant questions related to colorectal cancer screening and surveillance after polypectomy.

Model Comparison Grid (PDF, 398 KB)

Individual Models

• MISCAN-Colon (Erasmus/MSK) (PDF, 726 KB)
• SimCRC (Minnesota/MGH) (PDF, 378 KB)
• CRC-SPIN (FHCC) (PDF, 536 KB)

Historical Versions

Gastric model profiles

The CISNET Gastric Cancer Working group is using their 3 models to provide critical evidence to improve the prevention and early detection of gastric cancer and to improve cancer care.

Model Comparison Grid (PDF, 151 KB)

Individual Models

• GSiMO (Columbia) In progress
• Harvard-GC (BCH) In progress
• MISCAN-gastric (Erasmus) In progress

Historical Versions

Lung model profiles

The CISNET-Lung models incorporate information from the two largest trials on lung cancer screening in the U.S.: the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO) and the National Lung Screening Trial (NLST). The models were used to inform the United States Preventive Services Task Force on their recommendations for lung cancer screening.

Model Comparison Grid (PDF, 161 KB)

Individual Models

• BCCRI-LunCan (BCCRI) In progress
• BCCRI-Smoking (BCCRI) In progress
• LCOS (Stanford) In progress
• LCPM (MGH) In progress
• MISCAN-Lung (Erasmus) In progress
• SimSmoke (Georgetown) In progress
• Smoking-Lung Cancer (Georgetown)
• MULU (Mount Sinai) In progress
• ENGAGE (MDACC) In progress
• YLCM (Yale) In progress
• LMO (FHCC) (Historical) (PDF, 849 KB)
• OncoSim-Lung (CPAC-StatCan) In progress

Historical Versions

Multiple Myeloma model profiles

The three multiple myeloma models have been built using the latest real-world evidence and are addressing critical knowledge gaps in across the multiple myeloma care continuum.

Model Comparison Grid (PDF, 71 KB)

Individual Models

• WUMM-DES (Washington University) In progress
• WUMM-CM (Washington University) In progress
• YU-MM (Yale University) In progress

Historical Versions

Prostate model profiles

MISCAN-PRO (Erasmus) is a microsimulation model that allows tumor grade to progress over time, and a formal linking between cancer progression and biomarker growth is under active development. PSAPC (FHCC) is a microsimulation model that doesn't allow tumor grade to progress over time, and cancer progression is formally linked to biomarker growth. SCANS (Michigan) is an analytic mathematical model that allows tumor grade to progress over time, and cancer progression is not formally linked to biomarker growth.

Individual Models

• MISCAN-PRO (Erasmus) (PDF, 312 KB)
• PSAPC (FHCC) (PDF, 1.4 MB)
• SCANS (Michigan) (PDF, 1.9 MB)

Historical Versions

Uterine model profiles

The three uterine cancer modeling groups are using their natural history models to help identify optimal screening and detection strategies for uterine cancer across the risk spectrum.

Model Comparison Grid (PDF, 115 KB)

Individual Models

• CU-UTMO (Columbia) In progress
• DU-CAM (Duke) In progress
• MUSIC (Mount Sinai) In progress

Historical Versions

Esophageal cancer models (Historical)

The primary differences between the CISNET Esophageal models are in the modeling methodology. The MSEAC (FHCRC) model is a biologic model based on the paradigm of initiation, promotion, and progression, where carcinogenesis comprises the accumulation of mutations and clonal expansion of partially altered cells on the pathway to malignancy. The EACMo (CUIMC) and MISCAN-ESO (Washington/Erasmus) models focus on malignant mutations defined as health states on individual level rather than cell level.

Joint Profiles - all profiles combined (PDF, 2.0 MB)

Individual Models

• EACMo (CUIMC) (PDF, 339 KB)
• MISCAN-ESO (Erasmus/UW) (PDF, 772 KB)
• MSCE-EAC (FHCC) (PDF, 1.1 MB)

Historical Versions